Preparation to regular meeting on ministers level in C5+1 format between central Asian countries and Untied States of America, which would be held in Tashkent on February 3, is carried out. As is known, this format presents multilateral mechanism of cooperation between five states of the region and USA. Proposals for cooperation in such spheres as strengthening of security and stability, development of trade and economic relations, environment protection and ecology are systematically reviewed under its framework. The agenda of coming meeting in the capital of Uzbekistan will include subjects of development of regional partnership in number of priority directions. It includes economy and energy, counteraction of modern dangerous threats and challenges such as terrorism, illegal drag and human trafficking and transboundary crime. Consolidation of efforts for support of regulation of situation in Afghanistan, its social and economic revival, connection to energy, transport and trade systems of Central Asia will be subject of interesting discussion. It is planned to adopt relative joint document by the outcomes of the meeting. At the session of the Government on January 24, Turkmen leader noted importance of C5+1 meeting in the beginning of February in the context of realization of exiting capabilities for strengthening and expansion of cooperation between Central Asian states and USA. Outlining Turkmen – American relations, the Head of the State highlighted their constructive and steadfast character.